Cognitive behavioral therapy for body image and self-care (CBT-BISC) in sexual minority men living with HIV: a randomized controlled trial

OBJECTIVE: Body image disturbance is a distressing and interfering problem among many sexual minority men living with HIV, and is associated with elevated depressive symptoms and poor HIV self-care (e.g., antiretroviral therapy [ART] nonadherence). The current study tested the preliminary efficacy of a newly created intervention: cognitive–behavioral therapy for body image and self-care (CBT-BISC) for this population. METHOD: The current study entailed a 2-arm randomized controlled trial (N = 44) comparing CBT-BISC to an enhanced treatment as usual (ETAU) condition. Analyses were conducted at 3 and 6 months after baseline. The primary outcome was body image disturbance (BDD-YBOCS), and secondary outcomes were ART adherence (electronically monitored via Wisepill), depressive symptoms (MADRS), and global functioning (GAF). RESULTS: At 3 months, the CBT-BISC condition showed substantial improvement in BDD-YBOCS (b = −13.6, SE = 2.7, 95% CI [−19.0, −8.3], p < .001; dppc2 = 2.39); MADRS (b = −4.9, SE = 2.8, 95% CI [−10.6, .70], p = .086; dppc2 = .87); ART adherence (b = 8.8, SE = 3.3, 95% CI [2.0, 15.6], p = .01; dppc2 = .94); and GAF (b = 12.3, SE = 3.2, 95% CI [6.1, 18.6], p < .001; dppc2 = 2.91) compared with the ETAU condition. Results were generally maintained, or improved, at 6 months; although, adherence findings were mixed depending on the calculation method. CONCLUSIONS: CBT-BISC shows preliminary efficacy in the integrated treatment of body image disturbance and HIV self-care behaviors among sexual minority men living with HIV. (APA PsycInfo Database Record (c) 2019 APA, all rights reserved)Funding from this project came from K23MH096647. Author time for Steven A. Safren was supported by K24DA040489 (formally K24MH094214). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. (K23MH096647; K24DA040489; K24MH094214)Accepted manuscrip

The impact of performance-based scripts on men’s sexual communication to peers

Gender norms related to sexual behavior have a pervasive impact on the psychosocial development of men. These norms have been theorized to influence the formation of male sexual scripts, including those that place high emphasis on performative abilities. While research has indicated that endorsing performance-based scripts can have negative consequences, little work has examined how this sexual ideology is communicated by men to their peer groups. Using structural equation modeling, the current study tested a model of openness to communicate sexual behavior that is incongruent with existing performance-based scripts. A sample of 424 men were recruited from a variety of Internet platforms to participate in a one-time online survey. Results demonstrated that endorsing performance-based scripts impeded men’s ability to discuss sexual behavior with male peers, female peers, and sexual partners. Men’s lack of transparency about particular sexual experiences may be contributing to harmful narratives that rigidly emphasize sexual performance

Contexts of concealment: Initial validation of three disclosure avoidance process measures

The choice to withhold subjective distress reflects a multifactorial decision highly sensitive to context. Unfortunately, existing measures are built on unidimensional models (i.e., concealment-disclosure as a single, bipolar dimension) and operationalize the construct as a stable trait. In this article, we outline the development and initial validation of a self-report inventory that accounts for problem-context and assesses multiple processes central to both the concealment and disclosure of emotional distress. Exploratory analysis of pilot items in Study 1 (male student sample; N = 373) guided subsequent item development and revisions to our conceptual model. In Study 2 (mixed-gender community sample; N = 297), we refined the item-pool based on additional tests of latent scale structure and associations with concurrent criteria. In a final validation sample (Study 3; international community participants; N = 978), confirmatory factor analyses corroborated our hypothesized three-factor model (Privacy Management, Disclosure Desire, and Social Fear) and supported measurement invariance by sex. The three Contexts of Concealment Scales (CCS) were internally consistent and associated in expected directions with external indices of concurrent concealment, disclosure, depression, anxiety, loneliness, experiential avoidance, and self-stigma

Validation of the Glaucoma Filtration Surgical Mouse Model for Antifibrotic Drug Evaluation

Glaucoma is a progressive optic neuropathy, which, if left untreated, leads to blindness. The most common and most modifiable risk factor in glaucoma is elevated intraocular pressure (IOP), which can be managed surgically by filtration surgery. The postoperative subconjunctival scarring response, however, remains the major obstacle to achieving long-term surgical success. Antiproliferatives such as mitomycin C are commonly used to prevent postoperative scarring. Efficacy of these agents has been tested extensively on monkey and rabbit models of glaucoma filtration surgery. As these models have inherent limitations, we have developed a model of glaucoma filtration surgery in the mouse. We show, for the first time, that the mouse model typically scarred within 14 d, but when augmented with mitomycin C, more animals maintained lower intraocular pressures for a longer period of time concomitant with prolonged bleb survival to beyond 28 d. The morphology of the blebs following mitomycin C treatment also resembled well-documented clinical observations, thus confirming the validity and clinical relevance of this model. We demonstrate that the antiscarring response to mitomycin C is likely to be due to its effects on conjunctival fibroblast proliferation, apoptosis and collagen deposition and the suppression of inflammation. Indeed, we verified some of these properties on mouse conjunctival fibroblasts cultured in vitro. These data support the suitability of this mouse model for studying the wound healing response in glaucoma filtration surgery, and as a potentially useful tool for the in vivo evaluation of antifibrotic therapeutics in the eye

Traditional Masculinity Ideology and Diagnostic Aversion Predict Symptom Expression in a Community Sample of Distressed Men

Adherence to traditional masculinity ideology (TMI) is associated with a host of negative outcomes, including higher rates of internalizing and externalizing psychopathology. However, relatively less is known about the mechanisms and contexts through which TMI affects the expression of psychological distress. In the current study, men’s aversion to being diagnosed with a mental health disorder was tested as a mediator and moderator to help clarify the relationship between TMI and symptom expression. A community sample of 72 U.S. men experiencing elevated psychological distress completed self-report questionnaires during a single session. Results demonstrated that diagnostic aversion mediated the positive association between TMI and internalizing symptoms. In addition, diagnostic aversion moderated the positive association between TMI and externalizing symptoms, such that this association was stronger among men who demonstrated higher levels of diagnostic aversion. Aversion to mental health diagnosis may be important in understanding how men who adhere to TMI manifest distress across diagnostic categories